A Dandenong woman and men from Springvale, Dandenong and Hampton Park were arrested during drug raids on 13 properties.
Caulfield Divisional Response Unit (DRU) members charged 11 people over the ice crackdown, conducted on Monday 15 August.
It was the culmination of a 10-month investigation and allegedly disrupted an organised crime syndicate trafficking and distributing methamphetamine.
Properties in Springvale South, Hampton Park and Dandenong were among those the police searched.
They also executed warrants in Chelsea, Aspendale, Notting Hill, Cheltenham, Moorabbin, Seaford, Frankston, Mordialloc and Braeside.
Officers found a clandestine laboratory, a substantial amount of methamphetamine, other drugs including heroin and cannabis, a significant quantity of cash, an imitation firearm, two samurai swords, stolen property and drug paraphernalia.
They issued a 22-year-old Springvale man a caution regarding cannabis possession.
A man and woman from Dandenong, both 26, were released and are expected to be charged on summons with trafficking methylamphetamines.
A 29-year-old Hampton Park man was to face an out-of-sessions court hearing on Monday night.
Detective Senior Sergeant Shane Rix said the culmination of the operation was significant within the region and will disrupt the flow of methamphetamine onto the streets.
“Make no mistake, the arrests today have dismantled an organised crime syndicate which until now has profited from our community,” he said.
“What we have seen is the syndicate traffick drugs for stolen property and steal from our communities; this is not good enough and the arrests show the commitment of our members to get these people off our streets.
“Unfortunately, the demand for these types of illicit substances continues to grow, so those who use and buy need to know they are contributing to organised crime.
“While the operation and the warrants today have made a significant impact on the syndicate, we still have more work to do and the investigation is ongoing.”
Caulfield DRU members carried out the investigation with help from Moorabbin, Mordialloc, Cheltenham, Chelsea and Bayside local police, Kingston and Bayside CIU detectives, and specialist units including the Dog Squad and Divisional Tasking Unit.